Bone Abstracts

Background: Collagen has biocompatibility and biodegradability with tissue or organ, therefore, collagen is the most promising material for tissue engineering. In particular, the binding of collagen to specific cells is considered an essential function to develop scaffolds. However, in some cases the binding inhibits the cell motility. In addition, it is not clear whether collagen is the effective scaffold to promote osteogenic differentiation. These days, we succeeded in deve...

Background: Three-dimensional scaffolds for the tissue regeneration are also crucial materials for bone formation. In particular, the scaffolds must provide the space for the cell migration and new bone formation. Collagen is one of the useful scaffolds to reach these performance, however, it is not always a desired biodegradability. Recently, we succeeded in developing low adhesive scaffold type I collagen (LASCol) (patent pending) which has the ability to form fibrils. In th...